The MAPK-activated protein kinases (MAPKAP kinases) MK2 and MK3 are directly activated via p38 MAPK phosphorylation, stabilize p38 by complex formation, and donate to the strain response. p38 inhibitors on K8-Ser73 phosphorylation also confirmed decreased phosphorylations of keratins K18-Ser52 and K20-Ser13 however, not of K8-Ser431 or K18-Ser33. Oddly enough, K18-Ser52 and K20-Ser13 aren’t straight phosphorylated… Continue reading The MAPK-activated protein kinases (MAPKAP kinases) MK2 and MK3 are directly