DOT1-like protein (Dot1L) is the sole methyltransferase for methylation of lysine 79 in histone H3. DOT1-like protein, ovarian cancer, cell invasion, cancer stem cell, Wnt signaling Introduction Post-translational modifications of histone are emerging as essential mechanisms to regulate gene expression. Distinct modifications of histone have been determined and well proven, including acetylation, methylation, phosphorylation, sUMOylation… Continue reading DOT1-like protein (Dot1L) is the sole methyltransferase for methylation of lysine