BACKGROUND & AIMS IL-10 deficient mice develop TH1/TH17-mediated colitis and IL-10-producing regulatory T cells suppress colitis implicating IL-10 in maintaining mucosal homeostasis. GF or SPF IL-10 ko or wt mice induced more serious colitis and improved mucosal proinflammatory cytokines in IL-10 ko Rag2?/? than in wt Rag2?/? recipients. Either ko or wt Compact disc4+ cells… Continue reading BACKGROUND & AIMS IL-10 deficient mice develop TH1/TH17-mediated colitis and IL-10-producing