The premature stop codon mutations, Q70X and W402X, are the most

The premature stop codon mutations, Q70X and W402X, are the most common -l-iduronidase gene (IDUA) mutations in mucopolysaccharidosis type I (MPS I) patients. I) is an autosomal recessive lysosomal storage disorder caused by a deficiency in the lysosomal exo-hydrolase, -l-iduronidase (Neufeld and Muenzer 1995). MPS I individuals exhibit medical symptoms that include mental retardation, physical… Continue reading The premature stop codon mutations, Q70X and W402X, are the most