Unusual phosphorylation (hyperphosphorylation) and aggregation of Tau protein are hallmarks of

Unusual phosphorylation (hyperphosphorylation) and aggregation of Tau protein are hallmarks of Alzheimer disease and various other tauopathies, but their causative connection is a matter of debate still. after purification, the extremely phosphorylated proteins shaped oligomers, whereas fibrils rarely were observed only. Exposure of older primary neuronal civilizations to oligomeric phospho-Tau triggered reduction of backbone thickness… Continue reading Unusual phosphorylation (hyperphosphorylation) and aggregation of Tau protein are hallmarks of