epithelial and stromal expression of the secreted glycoprotein Dickkopf-related protein (Dkk)-3 is usually altered in age-related proliferative disorders of the human prostate. did not affect subcellular localization or levels of β-catenin but attenuated AKT phosphorylation in PrSCs. Consistently the PI3K/AKT inhibitor LY294002 mimicked the effects of knockdown. CONCLUSIONS?Dkk-3 promotes Belinostat (PXD101) fibroblast proliferation and myofibroblast… Continue reading epithelial and stromal expression of the secreted glycoprotein Dickkopf-related protein (Dkk)-3