Background Clinical efficacy of chemotherapy in colorectal cancer is usually subjected to broad inter-individual variations leading to the inability to predict outcome and toxicity. colorectal malignancy cells LS174T, SW480 and SW620 by transfection and siRNA strategies. Cellular response to irinotecan and its active metabolic SN38 was assessed by cell viability assays, HPLC metabolic information and… Continue reading Background Clinical efficacy of chemotherapy in colorectal cancer is usually subjected