Purpose 3-[18F]fluoro-3-deoxythymidine ([18F]FLT) is definitely phosphorylated by thymidine kinase 1 (TK-1),

Purpose 3-[18F]fluoro-3-deoxythymidine ([18F]FLT) is definitely phosphorylated by thymidine kinase 1 (TK-1), a cell cycle regulated enzyme. 10C14]. It offers been demonstrated that the metabolic mechanism of FLT is definitely centered on phosphorylation in the DNA synthesis pathway. Once [18F]FLT enters into the cells by a specific transporter, it is definitely phosphorylated to FLT 5-monophosphate (FLTMP)… Continue reading Purpose 3-[18F]fluoro-3-deoxythymidine ([18F]FLT) is definitely phosphorylated by thymidine kinase 1 (TK-1),