Left ventricular (LV) volume overload (VO) results in cardiomyocyte oxidative stress and mitochondrial dysfunction. experienced extensive loss of desmin and 2-tubulin that was paralleled by mitochondrial disorganization, loss of cristae, swelling, and clustering recognized by mitochondria complex IV staining and transmission electron microscopy. MitoQ improved mitochondrial structural damage and attenuated desmin loss/degradation evidenced by immunohistochemistry… Continue reading Left ventricular (LV) volume overload (VO) results in cardiomyocyte oxidative stress