P73 one person in the tumor suppressor p53 family stocks structural and functional similarity to p53 Soyasaponin BB highly. proteins kinase kinase-4 (MKK4). Inhibition of JNK activity by a particular inhibitor or little interfering RNA (siRNA) considerably abrogated TAp73-mediated apoptosis induced by cisplatin. Furthermore inhibition of GADD45α by siRNA inactivated MKK4/JNK activities and blocked TAp73-mediated… Continue reading P73 one person in the tumor suppressor p53 family stocks structural