Supplementary Materials1. coupling nutrient status to adipocyte-mediated adipokine secretion including Glucagon-mediated calcium signaling and GRASP, an unconventional secretion protein. In fly fat cells, Leptin ortholog Upd2 is usually associated with GRASP near lipid droplets and upon nutrient deprivation, increased calcium levels negatively regulates adipokine secretion via GRASP. Open in a separate window Introduction Energy homeostasis… Continue reading Supplementary Materials1. coupling nutrient status to adipocyte-mediated adipokine secretion including Glucagon-mediated