SREBP1c is an integral lipogenic transcription factor activated by insulin in the postprandial state. its binding to the ubiquitin E3 ligase MDM2. Although SREBP1c JIP2 fails to upregulate CRY1 expression in mice overexpression of CRY1 attenuates hyperglycaemia through reduction of hepatic FOXO1 protein and gluconeogenic gene expression. These data suggest that insulin-activated SREBP1c downregulates gluconeogenesis… Continue reading SREBP1c is an integral lipogenic transcription factor activated by insulin in