Mutations in the gene encoding Bruton’s tyrosine kinase (known to cause the xid phenotype prevents BCR-induced activation of NF-B. in number to 50% relative to wild type. The xid B cells that remain secrete reduced levels of serum IgM and IgG3, fail to respond to T cellCindependent type II antigensand are unable to proliferate in… Continue reading Mutations in the gene encoding Bruton’s tyrosine kinase (known to cause