Objective Menopausal age could affect the risk of developing cardiovascular disease (CVD). for women with and without early menopause respectively. The mean (SD) age was 65 (10.1) and 65 (8.9) years for women with and without early menopause respectively. There were no significant interactions between Biapenem menopausal age and ethnicity. In Rabbit polyclonal to APAF1. multivariable analysis early menopause was associated with a 10.7% increase in NT-proBNP while each year increase in menopausal age was associated with a 0.7% decrease in NT-proBNP. Conclusion Early menopause is associated with greater NT-proBNP levels while each year Biapenem increase in menopausal age is associated with lower NT-proBNP levels in postmenopausal women. <0.0001) and Hispanics (p=0.007). In those without early menopause the medians of NT-proBNP were significantly greater in Whites when compared to Chinese-Americans (p<0.0001) African-Americans (p<0.0001) and Hispanics (p<0.0001). The medians of NT-proBNP were also significantly greater in Hispanics when compared to Chinese-Americans (p=0.03) and African-Americans (p<0.0001) in women without early menopause. Current cigarette smoking and hypertension were most common in African-Americans in both postmenopausal groups. BMI was greatest in African-Americans but lowest in Chinese-Americans in both postmenopausal groups (supplemental tables 3 and 4). Figure 1 Figure 1a. Data points represent median (25th and 75th percentile) for each ethnicity. Early menopause was associated with a 10.7% increase in NT-proBNP while each year increase in menopausal age was associated with a 0.7% decrease in NT-proBNP (model 4 table 2). Similar estimates were obtained when LVH was replaced by LVM (model 5 table 2). Our point estimates were similar when BMI was substituted with WC because early menopause was associated with a 10.7% increase in NT-proBNP while each year increase in menopausal age was associated with a 0.8% decrease in NT-proBNP. In women without diabetes (n=1987) the estimates did not differ much because early menopause was associated with a 7.3% increase in NT-proBNP while each year increase in menopausal age was associated with a 0.7% decrease in log NT-proBNP. In analysis involving women aged 65 years and younger the patterns of association remained similar (table 3). Table 2 Percentage differences in NT-pro brain natriuretic peptide (NT-proBNP) levels associated with early menopause in postmenopausal women at MESA baseline Table 3 Percentage differences in NT-pro brain natriuretic peptide (NT-proBNP) levels associated with Biapenem early menopause in postmenopausal women aged 65 years or younger at MESA baseline Biapenem We presented ethnic-specific analysis in supplemental table 5. Due to inadequate power we cannot make certain conclusions however the percentage variations in NT-proBNP connected with early menopause tended to become higher in African-Americans. We advise extreme caution in interpretations linked to this Biapenem evaluation especially in Chinese-Americans and advise that ethnic-specific evaluation ought to be pursued in effectively powered studies. There is no significant collinearity as the variance inflation elements and the problem indices had been <5 for many terms in your versions. The percentage of lacking ideals was <3% for many variables therefore test sizes may possess varied slightly between your models. Discussion Inside our multi-ethnic test of postmenopausal ladies without medical CVD early menopause was connected with higher NT-proBNP whilst every year upsurge in menopausal age group was connected with lower NT-proBNP. This association was significant after modifying for CVD risk elements and constant in non-diabetic and young participants. Our findings remained consistent when LVH was assessed by MRI which is a more sensitive measure of cardiac remodelling.32 Our findings agree with our prior study which showed that early menopause is associated with an increased risk of incident HF.4 NT-proBNP has been linked to an increased risk of future HF15 and reliably predicts HF in multiple ethnicities.15 Early menopause was most common in African-Americans and least common in Chinese-Americans. We observed ethnic variations in NT-proBNP because greater levels were observed in White women relative to other ethnicities. However we failed to.