Opioids represent effective drugs for the relief of pain yet chronic opioid use often leads to CH5132799 a state of increased sensitivity to pain that is exacerbated during withdrawal. systemic administration of the CRF1 receptor antagonist MPZP (20 mg/kg) alleviated withdrawal-induced mechanical hypersensitivity. In contrast several functional adrenergic system antagonists (clonidine prazosin propranolol) failed to… Continue reading Opioids represent effective drugs for the relief of pain yet chronic