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Discovery and optimization of potent BCL-2 Inhibitors

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For instance, the function of high-dose methotrexate remains controversial, using a few randomized research reporting it never to be a significant element of therapy, while some reported that it had been
2009
The Pharmacophore based features exist at similar distances in the respective screened compounds of was used as decoy set, which comprises over 9,000 structurally diversified molecules initially filtered to obtain candidates through the use of MOE software filter dwas, removed all those compounds which deviate from Lipinski rule of five and adhere to medication ability criteria, unwanted initially, reactive highly, toxic and the ones compounds which deviate from (ROF), and still have poor bio-availability, were taken off the candidates from candidates
Probably, the primary reason for overlooking the real pH/glycolysis relationship, or at least to be given a second role at that best period was that, through the 70s and 60s, the required technology to measure pHi had not been available [58]

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Discovery and optimization of potent BCL-2 Inhibitors

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