J

J. makes them amenable for interesting pharmacologic applications, for example for compounds with CO donating properties. 83.6 (C5H4); 84.9 (C5H4); 102.6 (C5H4ipso); 111.6 (C6H4); 127.8 (C6H4); 131.4 (CH=N); 134.4 (C6H4); 147.7 (C6H4); 194.4 (Re-CO). Mass spectrum (based on 187Re) (5.05 (t, 2H, 82.5(C5H4); 83.0 (C5H4); 98.3 (C5H4ipso); 111.6 (C6H4); 127.8 (C6H4); 132.5 Clozic (CH=N); 134.4 (C6H4); Clozic 148.2 (C6H4); MnCCO (not observed). Mass spectrum (66.9 (C5H4); 68.9 (C5H5); 69.4 (C5H4); 80.9 (C5H4ipso); 111.0 (C6H4); 127.8 (C6H4); 133.1 (C6H4); 139.7 (CH=N); 148.6 (C6H4). Mass spectrum (2.02 (s, 3H, CH3); 5.74 (t, 2H, 21.4 (CH3); 85.9 (C5H4); 86.3 (C5H4); 103.6 (C5H4ipso); 128.9 (C6H4); 130.8 (C6H4); 138.4 (C6H4); 140.3 (C=N); 147.8 (C6H4); 194.9 (Re-CO). Mass spectrum (based on 187Re) (2.10 (s, 3H, CH3); 4.92 (s, 2H, C5H4); 5.43 (t, 2H, C5H4); 6.90 (s, 2H, NH2); 7.85 (d, 2H, 2.11 (s, 3H, CH3); 3.99 (s, 5H, C5H5); 4.30 (s, 2H, C5H4); 4.82 (s, 2H, C5H4); 6.76 (s, 2H, NH2); Rabbit polyclonal to APCDD1 7.43 (d, 2H, 2.1 for compounds 1b, 2b and 3b. These results are in agreement with the ideals reported for organic39 and organometallic analogues40,41. In addition, the resonances observed between 8.16 and 7.11?ppm were assigned to the hydrogen atoms of the C6H4 ring. As per literature reports, the broad singlet observed at 6.90C6.28?ppm was assigned to the hydrogen nuclei of the SO2NH2 group42,43. Moreover, 1H NMR spectra for 1a-b and 2a-b showed units of resonances in the region of 6.31C4.92?ppm, which are ascribed to the protons of the cyrhetrenyl and cymantrenyl moieties44,45. On this regard, the ferrocenyl derivatives 3aCb exhibited resonances around 4.82C4.30 due to the non-equivalent alpha and beta protons containing in the substituted Cp ring and a singlet in the region of 4.17C3.99?ppm, which was assigned to the proton resonances of the unsubstituted cyclopentadienyl group46,47. The presence of the NH group authorized as a broad singlet in the range of 9.9C8.7?ppm. Related have been reported for additional organometallic to sylhydrazones48. It is important to note the chemical shifts of the NH resonance showed a clear dependence on the presence of the organometallic moiety bound to the iminic entity. In fact, the downfield shift observed for the cyrhetrenyl (1aCb) and cymantrenyl (2aCb) tosyl HYDs ( 0.30) compared with ferrocenyl analogues (3aCb) can be related to the electron-withdrawing properties of the (5-C5H4)M(CO)3 moieties49, which produce a deshielding of the NH resonance, as a result, suggesting that the nature of the organometallic platform modifies the degree of electronic delocalisation within the CC(R) = NCNHC unit. We have found related results for ferrocenyl and cyrhetrenyl 1,3,4-thiadiazoles50 and thiosemicarbazones51. The 13C NMR data will also be in agreement with the proposed constructions, that is, all compounds showed the carbon nuclei of the organometallic fragments, C=N bridge Clozic and phenyl moiety. As expected, the resonances for the carbon atoms of the CH3 and C6H4 organizations were observed at 21 and 155C110 and did not show any apparent variations from those reported for the organic52 and organometallic analogues48,53. The most important feature of the 13C NMR spectra is the presence of a low field resonance (148C131?ppm), which was assigned to the iminyl carbon [C=N]. The carbon chemical shifts of this group for 1a, 2a and 3a also showed a clear dependence on the electronic properties of the organometallic moiety attached to it. The upfield shift observed for the cyrhetrenyl (1a) and cymantrenyl (2a) tosyl HYDs (132?ppm) compared with the ferrocenic analogue (3a) (140?ppm) can also be related to the opposite electronic effects of these organometallic moieties. This proposal is in agreement with the trend observed in the resonance of Clozic the NH proton mentioned above. We previously reported related results for Schiff bases54, thiosemicarbazones51 and hydrazones55 comprising ferrocenyl and cyrhetrenyl moieties. This.