Background Lung cancer is still the leading cause of cancer-related deaths worldwide and novel therapeutic methods are urgently needed for efficient therapies. 24 h incubation, combinations of metformin and insulin, pioglitazone and insulin, DCA and insulin, resulted in increased amount of glucose uptake combined with increased apoptosis (P 0.0001). When chemotherapeutic brokers were added, the combinations Abiraterone manufacturer with pioglitazone were found with higher cytotoxicity when compared to chemotherapeutic Slc4a1 agents alone, except for the cisplatin combination (P 0.001). Conclusions Indeed, Metformin, pioglitazone and DCA have anti-cancer effect on small cell lung malignancy cell line which might be due to the higher amount of glucose uptake in Abiraterone manufacturer these cells. DCA and anti-diabetic brokers suppose a great advantage for a future therapeutic use in combination with antineoplastic Abiraterone manufacturer brokers in lung malignancy patients. strong class=”kwd-title” Keywords: Small cell lung malignancy, glucose uptake, metformin.