Minimally invasive glaucoma surgeries (MIGS) can improve the conventional pressure dependent outflow by bypassing or ablating the trabecular meshwork or create alternative drainage routes into the suprachoroidal or subconjunctival space. in an anatomically highly confined space with semi-transparent tissues are fundamentally different from other anterior segment surgeries and present even experienced surgeons with a substantial learning curve. Here we provide practical tips and review techniques and outcomes of TM bypass and ablation MIGS. (Glaukos Corporation Laguna Hills CA USA) is 0.4 mm long 0.3 mm wide and consists of titanium with heparin coating. Two bullet-shaped stents are preloaded Cisplatin in an injector. This allows for perpendicular implantation into TM and penetration of the tip into Schlemm’s canal (SC) of both stents without withdrawing the inserter avoiding hypotony and reflux of blood from the collector channels and SC. Trabecular meshwork stents increase outflow by allowing aqueous to directly bypass the trabecular meshwork. Since SC is discontinuous and septated flow is not circumferential; [10 11 outflow segments may be accessed over approximately 60° with a single stent although individual anatomy varies.  Placement of a second stent may increase Cisplatin the number of drainage segments accessed and potentially lower IOP further. The preoperative regimen is identical to standard phacoemulsification. Following cataract extraction intracameral acetylcholine is used for miosis. The chamber is deepened with viscoelastic. Over-inflation must be avoided as it can collapse SC and lead to implantation of the device into the outer wall of SC instead Cisplatin of the TM while insufficient viscoelastic prevents proper angle visualization. After rotating the microscope the first stent is inserted with a gentle push into nasal TM under direct gonioscopic view Cisplatin and released from the inserter. The second stent is then placed at least two clock hours away from the first one (to increase the chance of accessing a different drainage segment). Viscoelastic and refluxing blood are aspirated and the stent placement is confirmed gonioscopically. The eye is pressurized with saline. A fluoroquinolone is given four times per day for just one week along with prednisolone acetate 1% 4-6 instances each day and tapered every week for all methods discussed Cisplatin here. Outcomes Outflow service doubled after placing one stent and doubled once again with two stents within an anterior chamber (AC) perfusion model. Twenty individuals inside a consecutive series had a mean IOP of 20 mmHg about 1. 3 medicines which was decreased to 17 mmHg (14% Cisplatin lower) on 0. 3 drops 12 months after mixed phacoemulsification and 2 stent placements. Unwanted effects included transient IOP spikes > 30 mmHg at postoperative day 1 in 15%. With four individuals although two stents had been regarded as inserted only 1 could be discovered. No patient dropped eyesight. iStent G1 Concept and Technique The 1st era iStent G1 (Glaukos Company Laguna Hillsides CA USA) can be three times bigger than the iStent Inject. After position visualization referred to above this product can be lightly leaned against the TM but somewhat left towards the contrary side from the chamber to supply a more directed engagement for much easier entry (Shape 2). Utilizing a mild sweeping movement the stent can be forced through the TM as the foundation can be kept parallel towards the iris. The stent is released and gently tapped Rabbit Polyclonal to ZAR1. having a leftward motion to properly insert it and travel it through the TM or free of charge it through the external wall. Shape 2 Engaging the TM using the iStent trabectome and G1. A more directed position (remaining inset) permits easier admittance into Schlemm’s canal (blue) in comparison to a parallel orientation (ideal inset). Outcomes A single stent doubled the outflow service in perfused donor insertion and eye of two stents quadrupled it all. An in-vivo analysis utilized fluorophotometry to verify that the keeping two stents with phacoemulsification increased trabecular outflow service by 275% over baseline while phacoemulsification alone increased it by just 46%. A prospective research showed that IOP decreased by 25% at six months while the amount of medications decreased from 1. 5 to at least one 1 (n=58). Only 3 instances (5%) had been advanced to trabeculectomy. At a year the IOP decrease averaged 18% and 62% individuals got an IOP <= 18.