The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows the generation of high-affinity antibody-producing plasma cells and memory B cells. interaction. In the context of GCs, which contain large numbers of cells in a highly compacted structure, focused delivery of signals across the interacting cells becomes particularly important. Promiscuous or bystander… Continue reading The germinal center (GC) is a complex, highly dynamic microanatomical niche
Tag: Vandetanib enzyme inhibitor
Objective Matrix fragments, including fibronectin fragments (Fnf), accumulate during the development
Objective Matrix fragments, including fibronectin fragments (Fnf), accumulate during the development of osteoarthritis (OA) stimulating chondrocyte matrix metalloproteinase (MMP) production. CA-Rac improved MMP-13. Inhibition of Rho-associated kinase experienced no effect. EGF and TGF, but not Fnf, improved Rac1 activity and advertised the increase in MMP-13 above that stimulated by Fnf only. Active Rac was recognized… Continue reading Objective Matrix fragments, including fibronectin fragments (Fnf), accumulate during the development