Background em XPC /em is definitely involved in the nucleotide excision restoration of DNA damaged by carcinogens known to cause bladder cancer. The two 3’UTR variants were associated with Rabbit polyclonal to ZC3H12D reduced protein and mRNA manifestation in plasmid-based assays, suggesting an effect on mRNA stability and/or transcription/translation. A near-significant reduction in XPC protein… Continue reading Background em XPC /em is definitely involved in the nucleotide excision