Pulmonary edema is usually mediated partly by disruption of interendothelial cell contacts. interendothelial staining of adherens junction complex-associated protein upon SHP2 inhibition. Finally immunoprecipitation and immunoblot analyses confirmed elevated tyrosine phosphorylation of VE-cadherin β-catenin and p190RhoGAP proteins aswell as reduced association between p120-catenin and VE-cadherin proteins. Our results claim that SHP2 facilitates basal pulmonary endothelial… Continue reading Pulmonary edema is usually mediated partly by disruption of interendothelial cell