NEMO (NF-κB essential modulator) associates using the catalytic subunits IKKα and IKKβ to create the WeκB kinase (IKK) organic and is an integral regulator of NF-κB pathway signaling. NEMO SRT3109 binds a 44-mer peptide encompassing residues 701-745 of IKKβ with KD = 2.2 ± 0.8 nM. The IKKβ binding affinities of mutants with five and… Continue reading NEMO (NF-κB essential modulator) associates using the catalytic subunits IKKα and