ATF6α a membrane-anchored transcription factor through the endoplasmic reticulum (ER) that modulates the cellular response to stress as an effector of the unfolded-protein response (UPR) is a key player in the development of tumors of different origin. isomerase A5 (PDIA5) as necessary for ATF6α activation upon ER stress. PDIA5 contributed to disulfide bond SORBS2 rearrangement… Continue reading ATF6α a membrane-anchored transcription factor through the endoplasmic reticulum (ER) that