Mutational activation of the phosphatidylinositol 3-kinase (PI3K) pathway occurs in a wide variety of tumors whereas activating Wnt pathway mutants are predominantly found in colon cancer. model signals transduced through different pathways are integrated at the level of the regulatory elements of individual genes. Such regulatory elements may be viewed as assemblies of cis-acting response… Continue reading Mutational activation of the phosphatidylinositol 3-kinase (PI3K) pathway occurs in a