Supplementary Materialsdata health supplement. patient with T-PLL with a clonal V658F mutation that responded to ruxolitinib therapy. After relapse developed, an expanded clone that harbored mutant M511I and downregulation of the phosphatase, GW 4869 kinase activity assay Rabbit Polyclonal to PLCB3 CD45, was identified. We demonstrate that the missense mutations were activating, caused pathway hyperactivation,… Continue reading Supplementary Materialsdata health supplement. patient with T-PLL with a clonal V658F