Replicative cellular senescence is an important tumor suppression mechanism and also contributes to aging. open, and the transcription of satellite sequences increases. The peripheral heterochromatic compartment (PHC) becomes less prominent, and centromere structure becomes notably enlarged. These epigenetic changes progress slowly after the onset of senescence, with some, such as mobilization of retrotransposable elements, becoming… Continue reading Replicative cellular senescence is an important tumor suppression mechanism and also