Supplementary MaterialsSupplementary Physique Legend 41375_2019_403_MOESM1_ESM. 1 and 3 (RUNX1 and RUNX3) as interactors of IKZF1 and IKZF3. Relationship with RUNX3 and RUNX1 inhibits CRBN-dependent binding, ubiquitylation, and degradation of IKZF1 and IKZF3 upon lenalidomide treatment. Inhibition of RUNXs, via hereditary ablation or a little molecule (AI-10-104), leads to sensitization of myeloma cell lines and principal… Continue reading Supplementary MaterialsSupplementary Physique Legend 41375_2019_403_MOESM1_ESM. 1 and 3 (RUNX1 and RUNX3)