Rhodopsin is a cilia-specific GPCR essential for vision. further facilitated the

Rhodopsin is a cilia-specific GPCR essential for vision. further facilitated the mislocalization. This collective mistrafficking signal confers toxicity to rhodopsin and causes mislocalization when the VXPX cilia-targeting motif is absent. We also determined that the VXPX motif neutralizes this mistrafficking signal enhances ciliary targeting at least 10-fold and accelerates trafficking of post-Golgi vesicular structures. In… Continue reading Rhodopsin is a cilia-specific GPCR essential for vision. further facilitated the