The effect of Pgp induction in rats by pregnenolone 16-carbonitrile (PCN) (3 times, 35 mg/kg/d, p. intestinal secretory transport could effect on efficacy or bring about toxicity significantly. Known drug-drug connections (DDIs) effecting digoxin therapy have already been highlighted by prior research [4,5]. In guy, Drescher [5], using segmental perfusion of jejunum, show direct luminal… Continue reading The effect of Pgp induction in rats by pregnenolone 16-carbonitrile (PCN)