Adeno-associated virus (AAV) inverted terminal repeats (ITRs) are key elements of AAV. of the rAAV genome. It has been shown that rAAV genomes can be replicated, even with incomplete, truncated, or imperfect ITR sequences, leading to the production of rAAV vectors in transfection experiments. Nonetheless, it was hypothesized that unmodified wild-type (WT) ITR sequences could… Continue reading Adeno-associated virus (AAV) inverted terminal repeats (ITRs) are key elements of