Supplementary Materials Supplementary data bj3940399add. that ecLeuRS-ED uses a lock-and-key mechanism to recognize and discriminate between the amino acids. Structural comparison also reveals that all subclass Ia aaRSs share a conserved structure core consisting of the editing domain name and conserved residues at the editing active site, suggesting that these enzymes may use a common… Continue reading Supplementary Materials Supplementary data bj3940399add. that ecLeuRS-ED uses a lock-and-key mechanism