Overexpression of mitochondria-bound hexokinase II (HKII) in tumor cells takes on an important part in their metabolic reprogramming and protects them against apoptosis, thereby facilitating their development and expansion. hypoxic circumstances of neoplastic mass accrual (1, 3). Among the 4 isoforms of mammalian hexokinase (HKICHKIV), just HKI and HKII straight interact with mitochondria, both literally… Continue reading Overexpression of mitochondria-bound hexokinase II (HKII) in tumor cells takes on