Supplementary MaterialsAuthor_Response_1 C Supplemental material for Rapid and precise diagnosis of pulmonary infection in a HIV-negative patient with autosomal-dominant mutation: a case report Author_Response_1. autosomal-dominant mutation: a case report File2-gene_detection.pdf (144K) GUID:?E59CC5F8-2145-4F83-B5EE-72021E9D49D4 Supplemental material, File2-gene_detection for Rapid and precise diagnosis of pulmonary infection in a HIV-negative patient with autosomal-dominant mutation: a case report by Wei Zhang, Jian Ye, Chenhui Qiu, Limin Wang, Weizhong Jin, Chunming Jiang, Lihui Xu, Jianping Xu, Yue Li, Liusheng Wang and Hualiang Jin in Therapeutic Advances in Respiratory Disease File_1-Methodology_of_the_next_generation C Supplemental material for Rapid and precise diagnosis of pulmonary infection in a HIV-negative patient with autosomal-dominant mutation: a case report File_1-Methodology_of_the_next_generation.pdf (42K) GUID:?9BBD1DEC-6266-4A42-955A-7AD8144C2D28 Supplemental material, File_1-Methodology_of_the_next_generation for Rapid and precise diagnosis of pulmonary infection in a HIV-negative patient with autosomal-dominant mutation: a case report by Wei Zhang, Jian Ye, Chenhui Qiu, Limin Wang, Weizhong Jin, Chunming Jiang, Lihui Xu, Jianping Xu, Yue Li, Liusheng Wang and Hualiang Jin in Therapeutic Advances in Respiratory Disease Reviewer_1_v.1 C Supplemental material for Rapid and precise diagnosis of pulmonary infection in a HIV-negative patient with autosomal-dominant mutation: a case report Reviewer_1_v.1.pdf (57K) GUID:?22D29061-C02C-48BE-AEF3-86783F145EEE Supplemental material, Reviewer_1_v.1 for Rapid and precise diagnosis of pulmonary infection in a HIV-negative patient with autosomal-dominant mutation: a case report by Wei Zhang, Jian Ye, Chenhui Qiu, Limin (-)-Epigallocatechin gallate price Wang, Weizhong Jin, Chunming Jiang, Lihui Xu, Jianping Xu, Yue Li, Liusheng Wang and Hualiang Jin in Therapeutic Advances in Respiratory Disease (-)-Epigallocatechin gallate price Reviewer_1_v.2 C Supplemental material for Rapid and precise diagnosis of pulmonary infection in a HIV-negative patient with autosomal-dominant mutation: a case report Reviewer_1_v.2.pdf (57K) (-)-Epigallocatechin gallate price GUID:?33DFF131-1D04-40E8-9BCD-432DC19D678B Supplemental material, Reviewer_1_v.2 for Rapid and precise diagnosis of pulmonary infection in a HIV-negative patient with autosomal-dominant mutation: a case report by Wei Zhang, Jian Ye, Chenhui Qiu, Limin Wang, Weizhong Jin, Chunming Jiang, Lihui Xu, Jianping Xu, Yue Li, Liusheng Hualiang and Wang Jin in Therapeutic Advancements in Respiratory Disease Reviewer_2_v.1 C Supplemental materials for Fast and specific diagnosis of pulmonary infection within a HIV-negative individual with autosomal-dominant mutation: an instance record Reviewer_2_v.1.pdf (65K) GUID:?05C7BF58-D924-4438-BF48-5A16C11396E1 Supplemental materials, Reviewer_2_v.1 for Fast and precise medical diagnosis of pulmonary infections within a HIV-negative individual with autosomal-dominant mutation: an instance record by Wei Zhang, Jian Ye, Chenhui Qiu, Limin Wang, Weizhong Jin, Chunming Jiang, Lihui Xu, Jianping Xu, Yue Li, Liusheng Wang and Hualiang Jin in Therapeutic Advancements in Respiratory Disease Data Availability StatementAvailability of data and components: The sequencing data helping our results is contained inside the manuscript and extra supporting files. The datasets used and/or analysed through the study can be found through the corresponding author on reasonable request also. Abstract History: pulmonary infections within a non-HIV-infected individual with (nucleotide sequences. Lifestyle of bronchoscopy specimens verified the outcomes. The individual was HIV harmful, and bloodstream gene recognition indicated mutation. To time, following the program of itraconazole, the individual satisfactorily provides recovered. Bottom line: In scientific practice, infections among HIV-negative people is certainly relatively rare, and we found that patients who are congenitally immunocompromised due to mutation may be potential hosts. Early diagnosis and timely treatment are expected to improve the prognosis of contamination. NGS is a powerful technique that may play an important role in this progress. mutation, contamination was reported in an American minister in Southeast Asia.2 The incidence rate of infection increased noticeably after the acquired immune deficiency syndrome (AIDS) pandemic in the 1980s.1 Contamination by is rarely reported in non-HIV-infected hosts,3 but in recent years the Rabbit Polyclonal to EDG4 incidence rate of infection in HIV-negative individuals is increasing 12 months by year. Many of the HIV-negative non-endemic patients had potentially immunocompromising conditions, such as autosomal dominant hyper-IgE syndrome (AD-HIES), hyper-IgM syndrome, immunosuppressive therapies, and being positive for anti-interferon-gamma autoantibody. Therefore, it is important to increase the diagnostic efficiency of this disease, especially in HIV-negative hosts, with a effective technique. Here, we report a rare case of a HIV-negative patient with lung contamination with a (2?days later (Table 1). About 1?week later, culture of BALF and the biopsied tissue mass also showed the presence of (Physique 3ACB). Table 1. NGS of BALF identified 566 nucleotide sequences. was determined by Sanger sequencing (c.92G A, p.R31Q). lung and mutation infections with pulmonary infections within a HIV-negative individual with mutation. The use of NGS in BALF assists the rapid diagnosis of infection greatly..