Predicated on the set ups of small-molecule strikes focusing on the HIV-1 gp41, or reaction was utilized to synthesize A1-A9 and A11-A20 from the condensation of anilines or benzylamines with 2,5-dimethoxytetrahydrofuran or acetonylacetone (hexane-2,5-dione),23 respectively. within the books,26 thiosemicarbazone (7) was ready from ppm 7.90 (1H, d, = 2.0 Hz, ArH-2), 7.75 (1H, dd, = 8.4 and 2.0 Hz, ArH-6), 7.60 (1H, d, = 8.4 Hz, ArH-5), 7.43 (2H, m, PyH-2,5), 6.29 (2H, t, = 2.2 Hz, PyH-3,4). MS (%) 221 (M+, 100), 223 (M+2, 36). Anal. (C11H8ClNO2) C, H, N. ppm 11.34 (1H, br, COOH), 7.82 (1H, d, = 2.8 Hz, ArH-2), 7.73 (1H, dd, = 9.2 and 2.8 Hz, ArH-6), 7.26 (2H, m, PyH-2,5), 7.07 (1H, d, = 9.2 Hz, ArH-5), 6.24 (2H, t, = 2.2 Hz, PyH-3,4); MS (%) 203 (M+, 100). Anal. (C11H9NO3) C, H. ppm Calcipotriol 13.18 (1H, br, COOH), 7.98 (1H, d, = 2.0 Hz, ArH-2), 7.80 (2H, dd, = 8.4 and 2.0 Hz, ArH-4,6), 7.57 (1H, t, = 8.4 Hz, ArH-5), 7.40 (2H, m, PyH-2,5), 6.26 (2H, t, = 2.2 Hz, PyH-3,4). MS (%) 187 (M+, 100). Anal. (C11H9NO2) C, H, N. ppm 8.19 (1H, d, = 2.0 Hz, ArH-2), 7.92 (1H, d, = 8.4 Hz, ArH-4), 7.83 (1H, dd, = 8.4 and 2.0 Hz, ArH-6), 7.71 (1H, t, = 8.4 Hz, ArH-5), 7.47 (2H, m, PyH-2,5), 6.35 (2H, t, = 2.2 Hz, PyH-3,4); MS (%) 211 (M+, 100). Anal. (C11H9N5) C, H, N. ppm 10.75 (1H, s, OH), 7.85 (1H, d, = 8.4 Hz, ArH-5), 7.52 (2H, m, PyH-2,5), 7.25 (1H, d, = 8.4 Hz, ArH-6), 7.23 (1H, s, ArH-2), 6.31 (2H, t, = 2.2 Hz, PyH-3,4), 3.91 (3H, s, OCH3). MS (%) 217 (M+, 100). Anal. (C12H11NO31/8 H2O) C, H, N. ppm 12.92 (1H, br, COOH), 8.01 (2H, d, = 8.4 Hz, ArH-3,5), 7.73 (2H, d, = 8.4 Hz, ArH-2,6), 7.50 (2H, m, PyH-2,5), 6.32 (2H, t, = 2.2 Hz, PyH-3,4); MS (%)187 (M+, 86). Anal. (C11H9NO2) C, H, N. ppm 12.38 (1H, br, COOH), 7.52 (2H, d, = 8.4 Hz, ArH-2,6), 7.34 (2H, m, PyH-2,5), 7.32 (2H, d, = 8.4 Hz, ArH-3,5), Calcipotriol 6.26 (2H, t, = 2.2 Hz, PyH-3,4), 3.59 (2H, s, CH2); MS (%) 201 (M+, 64). Anal. (C12H11NO21/8 H2O) C, H, N. ppm 13.94 (1H, br, COOH), 10.83 (1H, s, OH), 7.52 (1H, d, = Calcipotriol 8.4 Hz, ArH-5), 7.51 (2H, m, PyH-2,5), 7.25 Calcipotriol (1H, d, = 8.4 Hz, ArH-6), 7.22 (1H, s, ArH-2), 6.30 (2H, t, = 2.2 Hz, PyH-3,4); MS (%): 203 (M+, 100). Anal. (C11H9NO3) calcd C, H, N. ppm 12.92 (1H, br, COOH), 7.90 (2H, d, = 8.4 Hz, ArH-3,5), 7.24 (2H, d, = 8.4 Hz, ArH-2,6), 6.83 (2H, m, PyH-2,5), LSH 6.64 (2H, t, = 2.2 Hz, PyH-3,4), 5.19 (2H, s, CH2); MS (%) 201 (M+, 93). Anal. (C12H11NO2) C, H, N. HCl to pH 3. The solid was gathered, washed with drinking water, and purified with Adobe flash column [eluant: EtOAc/petroleum ether with AcOH (4:0.02), 0~20%] to cover 45 mg of A10, 84% produce, pale yellow stable, mp 106C109 C; 1H NMR ppm 12.28 (1H, br, COOH), 7.21 (2H, d, = 8.4 Hz, ArH-3,5), 7.12 (2H, d, = 8.4 Hz, ArH-2,6), 6.80 (2H, m, PyH-2,5), 6.01 (2H, Calcipotriol t, = 2.2 Hz, PyH-3,4), 5.06 (2H, s, N CH2), 3.53 (2H, s, -CH2CO); MS (%) 215 (M+, 98). Anal. (C13H13NO21/8 H2O) C, H, N. General process of the planning of ppm 13.63 (1H, br, COOH), 7.69 (1H, d, = 8.4 Hz, ArH-5), 7.61 (1H, d, = 2.0 Hz, ArH-2), 7.48 (1H, dd, = 8.4 and 2.0 Hz, ArH-6), 5.83 (2H, s, PyH), 1.98 (6H, s, Py-CH32); MS (%) 249 (M+, 100), 251 (M+2, 42). Anal. (C13H12ClNO2) C, H, N. ppm 11.50 (1H, br, COOH), 7.54 (1H, d, = 2.0 Hz, ArH-2), 7.43 (1H, dd, = 8.4 and 2.0 Hz, ArH-6), 7.09 (1H, d, = 8.4Hz, ArH-5), 5.78 (2H, s, PyH), 1.94 (6H, s, Py-CH32); MS (%) 231 (M+, 100). Anal. (C13H13NO31/8 H2O) C, H, N. ppm 13.18 (1H, br, COOH), 7.97 (1H, d, = 8.4 Hz, ArH-4), 7.65 (1H, s, ArH-2), 7.62 (1H, t, = 8.4 Hz, ArH-5), 7.52 (1H, d, = 8.4 Hz, ArH-6), 5.78 (2H, s, PyH), 1.92 (6H, s, Py-CH32); MS (%) 214 (M?H, 100). Anal. (C13H13NO2) C, H, N. ppm 8.14 (1H, d, = 8.4 Hz, ArH-4), 7.87 (1H, s, ArH-2), 7.76 (1H, t, = 8.4 Hz, ArH-5), 7.53 (1H, d, = 8.4 Hz, ArH-6), 5.85 (2H, s, PyH), 2.02 (6H, s, Py-CH32); MS (%) 239 (M+, 76). Anal. (C13H13N5) C, H, N. ppm 10.92 (1H, s, OH), 7.94 (1H, d, = 8.4 Hz, ArH-5), 6.86 (1H, d, = 2.0 Hz, ArH-2), 6.76 (1H, dd, = 8.4 and 2.0 Hz, ArH-6), 5.91 (2H, s, PyH), 3.99 (3H, s, OCH3), 2.08 (6H, s, Py-CH32); MS (%) 245 (M+, 100); HPLC purity 98.6 %. ppm.