Glycoprotein B (gB) enables the fusion of viral and cell membranes during access of herpesviruses. was generated by using random 5-amino-acid-linker insertion mutagenesis. Several mutants were unable to mediate cell-cell fusion despite becoming expressed within the cell surface. Mapping of the insertion sites onto the crystal structure of gB730 suggested that several insertions is probably… Continue reading Glycoprotein B (gB) enables the fusion of viral and cell membranes